Burnout (psychology) burnout is a pathologic syndrome in which prolonged occupational stress leads to emotional and physical depletion and ultimately to the development of maladaptive behaviors (e.g., cynicism, depersonalization, hostility, detachment).. Burnout is not a simple result of long hours. the cynicism, depression, and lethargy of burnout can occur when you're not in control of how you carry out your job, when you're working toward goals. Burnout robs the world of its best and its brightest by feeding on their energy, enthusiasm, and passion, transforming them into exhaustion, frustration, and disillusionment. but burnout isn't.